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Influence of the Gut Microbiota on the Development of Neurodegenerative Diseases.
Singh, Mahendra P; Chakrabarty, Riya; Shabir, Shabnam; Yousuf, Sumaira; Obaid, Ahmad A; Moustafa, Mahmoud; Al-Shehri, Mohammed; Al-Emam, Ahmed; Alamri, Abdulhakeem S; Alsanie, Walaa F; Alhomrani, Majid; Shkodina, Anastasiia D; Singh, Sandeep K.
Affiliation
  • Singh MP; School of Bioengineering and Biosciences, Lovely Professional University, Jalandhar-Ludhiana GT Road, Phagwara, 144411 Punjab, India.
  • Chakrabarty R; School of Bioengineering and Biosciences, Lovely Professional University, Jalandhar-Ludhiana GT Road, Phagwara, 144411 Punjab, India.
  • Shabir S; School of Bioengineering and Biosciences, Lovely Professional University, Jalandhar-Ludhiana GT Road, Phagwara, 144411 Punjab, India.
  • Yousuf S; School of Bioengineering and Biosciences, Lovely Professional University, Jalandhar-Ludhiana GT Road, Phagwara, 144411 Punjab, India.
  • Obaid AA; Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
  • Moustafa M; Department of Biology, College of Science, King Khalid University, 9004 Abha, Saudi Arabia.
  • Al-Shehri M; Department of Botany and Microbiology, Faculty of Science, South Valley University, Qena, Egypt.
  • Al-Emam A; Department of Biology, College of Science, King Khalid University, 9004 Abha, Saudi Arabia.
  • Alamri AS; Department of Pathology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
  • Alsanie WF; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Alhomrani M; Department of Clinical Laboratory Sciences, the Faculty of Applied Medical Sciences, Taif University, Taif, Saudi Arabia.
  • Shkodina AD; Centre of Biomedical Sciences Research (CBSR), Deanship of Scientific Research, Taif University, Saudi Arabia.
  • Singh SK; Department of Clinical Laboratory Sciences, the Faculty of Applied Medical Sciences, Taif University, Taif, Saudi Arabia.
Mediators Inflamm ; 2022: 3300903, 2022.
Article in En | MEDLINE | ID: mdl-36248189
ABSTRACT
Neurodegenerative disorders are marked by neuronal death over time, causing a variety of cognitive and motor dysfunctions. Protein misfolding, neuroinflammation, and mitochondrial and protein clearance system dysfunction have all been identified as common pathways leading to neurodegeneration in recent decades. An altered microbiome of the gut, which is considered to play a central role in diseases as well as health, has recently been identified as another potential feature seen in neurodegenerative disorders. An array of microbial molecules that are released in the digestive tract may mediate gut-brain connections and permeate many organ systems, including the nervous system. Furthermore, recent findings from clinical as well as preclinical trials suggest that the microbiota of the gut plays a critical part in gut-brain interplay and that a misbalance in the composition of the gut microbiome may be linked to the etiology of neurological disorders (majorly neurodegenerative health problems); the underlying mechanism of which is still unknown. The review aims to consider the association between the microbiota of the gut and neurodegenerative disorders, as well as to add to our understanding of the significance of the gut microbiome in neurodegeneration and the mechanisms that underlie it. Knowing the mechanisms behind the gut microbiome's role and abundance will provide us with new insights that could lead to novel therapeutic strategies.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurodegenerative Diseases / Microbiota / Gastrointestinal Microbiome Type of study: Prognostic_studies Limits: Humans Language: En Journal: Mediators Inflamm Journal subject: BIOQUIMICA / PATOLOGIA Year: 2022 Document type: Article Affiliation country: India

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurodegenerative Diseases / Microbiota / Gastrointestinal Microbiome Type of study: Prognostic_studies Limits: Humans Language: En Journal: Mediators Inflamm Journal subject: BIOQUIMICA / PATOLOGIA Year: 2022 Document type: Article Affiliation country: India