One-year aerobic exercise increases cerebral blood flow in cognitively normal older adults.
J Cereb Blood Flow Metab
; 43(3): 404-418, 2023 03.
Article
in En
| MEDLINE
| ID: mdl-36250505
ABSTRACT
The impact of aerobic exercise training (AET) on cerebral blood flow (CBF) regulation remains inconclusive. This study investigated the effects of one-year progressive, moderate-to-vigorous AET on CBF, central arterial stiffness, and cognitive performance in cognitively normal older adults. Seventy-three older adults were randomly assigned to AET or stretching-and-toning (SAT, active control) intervention. CBF was measured with 2D duplex ultrasonography. Central arterial stiffness, measured by carotid ß-stiffness index, was assessed with the ultrasonography and applanation tonometry. Cerebrovascular resistance (CVR) was calculated as mean arterial pressure divided by CBF. A cognitive battery was administered with a focus on memory and executive function. Cardiorespiratory fitness was measured by peak oxygen consumption (VËO2peak). One-year AET increased VËO2peak and CBF and decreased CVR and carotid ß-stiffness index. In the AET group, improved VËO2peak was correlated with increased CBF (r = 0.621, p = 0.001) and decreased CVR (r = -0.412, p = 0.037) and carotid ß-stiffness index (r = -0.478, p = 0.011). Further, increased Woodcock-Johnson recall score was associated with decreased CVR (r = -0.483, p = 0.012) and carotid ß-stiffness index (r = -0.498, p = 0.008) in AET group (not in SAT group). In conclusion, one-year progressive, moderate-to-vigorous aerobic exercise training increased CBF and decreased carotid arterial stiffness and CVR which were associated with improved memory function in cognitively normal older adults.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Exercise
/
Vascular Stiffness
/
Cardiorespiratory Fitness
Limits:
Adult
/
Humans
Language:
En
Journal:
J Cereb Blood Flow Metab
Year:
2023
Document type:
Article
Affiliation country:
United States