Early-immediate gene Egr1 is associated with TGFß1 regulation of epigenetic reader Bromodomain-containing protein 4 via the canonical Smad3 signaling in hepatic stellate cells in vitro and in vivo.

Tian, Haimeng; Xu, Feifan; Zhao, Feifei; Pan, Nachuan; Lu, Sidan; Jia, Xin; Zhou, Yajun

Tian, Haimeng; Xu, Feifan; Zhao, Feifei; Pan, Nachuan; Lu, Sidan; Jia, Xin; Zhou, Yajun.

Affiliation

Tian H; Department of Biochemistry & Molecular Biology, Medical School, Nantong University, Nantong, China.
Xu F; Department of Clinical Laboratory, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Nantong, China.
Zhao F; Department of Biochemistry & Molecular Biology, Medical School, Nantong University, Nantong, China.
Pan N; Department of Pathology and Laboratory Medicine, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Lu S; Department of Biochemistry & Molecular Biology, Medical School, Nantong University, Nantong, China.
Jia X; Department of Biochemistry & Molecular Biology, Medical School, Nantong University, Nantong, China.
Zhou Y; Department of Biochemistry & Molecular Biology, Medical School, Nantong University, Nantong, China.

FASEB J ; 36(11): e22605, 2022 11.

Article in En | MEDLINE | ID: mdl-36250963

Subject(s)

Chemical and Drug Induced Liver Injury, Chronic; Early Growth Response Protein 1; Hepatic Stellate Cells; Nuclear Proteins; Transcription Factors; Animals; Humans; Mice; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Chemical and Drug Induced Liver Injury, Chronic/metabolism; Early Growth Response Protein 1/genetics; Early Growth Response Protein 1/metabolism; Epigenesis, Genetic; Fibrosis; Hepatic Stellate Cells/metabolism; Liver Cirrhosis/chemically induced; Liver Cirrhosis/genetics; Liver Cirrhosis/metabolism; Nuclear Proteins/metabolism; Smad3 Protein/genetics; Smad3 Protein/metabolism; Thioacetamide/adverse effects; Transcription Factors/metabolism; Transforming Growth Factor beta1/metabolism

Key words

bromodomain containing protein 4; early growth response-1; hepatic stellate cells; liver fibrosis; transforming growth factor beta-1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Nuclear Proteins / Early Growth Response Protein 1 / Hepatic Stellate Cells / Chemical and Drug Induced Liver Injury, Chronic Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2022 Document type: Article Affiliation country: China Country of publication: United States

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