A potential serological biomarker for inner ear pathologies: OTOLIN-1.
Acta Otorhinolaryngol Ital
; 42(4): 364-371, 2022 Aug.
Article
in En
| MEDLINE
| ID: mdl-36254652
ABSTRACT
Objective:
The goal of the study was to determine whether the level of OTOLIN-1, a protein whose expression is highly restricted to the inner ear,is increased in the body fluids of patients with inner ear disorders in comparison to healthy subjects.Methods:
In the preliminary part of the study, OTOLIN-1 levels were measured in the serum, urine, and saliva of patients with an acute onset of Ménière´s disease and in healthy individuals. Subsequently, only serum OTOLIN-1 levels were taken into account and were compared between patients with acute onset of Ménière´s disease, sudden hearing loss, vestibular neuritis and healthy subjects.Results:
The most reliable diagnostic parameter was OTOLIN-1 levels in serum. Serum samples of patients with Ménière's disease and sudden hearing loss showed significantly higher OTOLIN-1 levels than those from healthy individuals. In addition, there was no significant difference between the serum concentration of OTOLIN-1 in patients with vestibular neuritis and the control group.Conclusions:
Serum levels of OTOLIN-1 can potentially be used as a biomarker for acute onset of inner ear disorders due to its significant increase in patients with acute Meniere´s disease and sudden hearing loss in comparison to healthy individuals.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Extracellular Matrix Proteins
/
Vestibular Neuronitis
/
Hearing Loss, Sudden
/
Ear, Inner
/
Meniere Disease
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Acta Otorhinolaryngol Ital
Year:
2022
Document type:
Article
Affiliation country:
Germany