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Mo154 Synergistically Enhanced Antibiofilm and Antibacterial Effects of Spermine via Coassembly.
Wang, Yu; Kong, Xueping; Li, Fei; Li, Bao; Wu, Lixin; Chen, Kai; Wu, Yuqing.
Affiliation
  • Wang Y; State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, No. 2699 Qianjin Street, Changchun 130012, P. R. China.
  • Kong X; State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, No. 2699 Qianjin Street, Changchun 130012, P. R. China.
  • Li F; State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, No. 2699 Qianjin Street, Changchun 130012, P. R. China.
  • Li B; State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, No. 2699 Qianjin Street, Changchun 130012, P. R. China.
  • Wu L; State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, No. 2699 Qianjin Street, Changchun 130012, P. R. China.
  • Chen K; Shangrao Normal University, College of Life Science, the Shangrao Innovation Institute of Agricultural Technology, Shangrao 334001, China.
  • Wu Y; State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, No. 2699 Qianjin Street, Changchun 130012, P. R. China.
ACS Appl Bio Mater ; 5(11): 5281-5288, 2022 11 21.
Article in En | MEDLINE | ID: mdl-36264761
ABSTRACT
Nowadays, the over use of antibiotics has led to the production of biofilms, which cause antimicrobial treatment to fail and thus are a severe threat to public health globally. Therefore, exploiting antibiofilm agents is highly urgent. In the present study, we report an assembly that is rationally constructed by biogenic amine spermine (Spm) and molybdenum (Mo)-containing polyoxometalate clusters (Mo154), which present efficient antibiofilm and bactericidal effects. On the one hand, the assembly of Mo154/Spm produces large aggregates, which favors 808 nm absorption and exhibits an improved photothermal transition (PTT) under near-infrared (NIR) irradiation. On the other hand, the assembly with Spm enhanced Mo154 uptake to both the biofilm and bacteria, which improved both biofilm elimination and antibacterial effects. Therefore, in addition to providing an efficient antibacterial agent of Mo154/Spm assembly, the present study also offers guidance on the future design of hybrid antibacterial assemblies with efficient effects.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spermine / Molybdenum Type of study: Guideline Language: En Journal: ACS Appl Bio Mater Year: 2022 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spermine / Molybdenum Type of study: Guideline Language: En Journal: ACS Appl Bio Mater Year: 2022 Document type: Article