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Marine Biological Macromolecules and Chemically Modified Macromolecules; Potential Anticoagulants.
Chandika, Pathum; Tennakoon, Pipuni; Kim, Tae-Hee; Kim, Se-Chang; Je, Jae-Young; Kim, Jae-Il; Lee, Bonggi; Ryu, BoMi; Kang, Hyun Wook; Kim, Hyun-Woo; Kim, Young-Mog; Kim, Chang Su; Choi, Il-Whan; Park, Won Sun; Yi, Myunggi; Jung, Won-Kyo.
Affiliation
  • Chandika P; Marine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University, Busan 48513, Korea.
  • Tennakoon P; Research Center for Marine Integrated Bionics Technology, Pukyong National University, Busan 48513, Korea.
  • Kim TH; Marine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University, Busan 48513, Korea.
  • Kim SC; Major of Biomedical Engineering, Division of Smart Healthcare and New-Senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan 48513, Korea.
  • Je JY; Marine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University, Busan 48513, Korea.
  • Kim JI; Research Center for Marine Integrated Bionics Technology, Pukyong National University, Busan 48513, Korea.
  • Lee B; Marine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University, Busan 48513, Korea.
  • Ryu B; Major of Biomedical Engineering, Division of Smart Healthcare and New-Senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan 48513, Korea.
  • Kang HW; Major of Human Bioconvergence, Division of Smart Healthcare, Pukyong National University, Busan 48513, Korea.
  • Kim HW; Major of Food Science and Nutrition, Pukyong National University, Busan 48513, Korea.
  • Kim YM; Major of Food Science and Nutrition, Pukyong National University, Busan 48513, Korea.
  • Kim CS; Major of Food Science and Nutrition, Pukyong National University, Busan 48513, Korea.
  • Choi IW; Marine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University, Busan 48513, Korea.
  • Park WS; Research Center for Marine Integrated Bionics Technology, Pukyong National University, Busan 48513, Korea.
  • Yi M; Major of Biomedical Engineering, Division of Smart Healthcare and New-Senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan 48513, Korea.
  • Jung WK; Marine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University, Busan 48513, Korea.
Mar Drugs ; 20(10)2022 Oct 21.
Article in En | MEDLINE | ID: mdl-36286477
Coagulation is a potential defense mechanism that involves activating a series of zymogens to convert soluble fibrinogen to insoluble fibrin clots to prevent bleeding and hemorrhagic complications. To prevent the extra formation and diffusion of clots, the counterbalance inhibitory mechanism is activated at levels of the coagulation pathway. Contrariwise, this system can evade normal control due to either inherited or acquired defects or aging which leads to unusual clots formation. The abnormal formations and deposition of excess fibrin trigger serious arterial and cardiovascular diseases. Although heparin and heparin-based anticoagulants are a widely prescribed class of anticoagulants, the clinical use of heparin has limitations due to the unpredictable anticoagulation, risk of bleeding, and other complications. Hence, significant interest has been established over the years to investigate alternative therapeutic anticoagulants from natural sources, especially from marine sources with good safety and potency due to their unique chemical structure and biological activity. This review summarizes the coagulation cascade and potential macromolecular anticoagulants derived from marine flora and fauna.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombosis / Anticoagulants Limits: Humans Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2022 Document type: Article Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombosis / Anticoagulants Limits: Humans Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2022 Document type: Article Country of publication: Switzerland