Mass photometry reveals SARS-CoV-2 spike stabilisation to impede ACE2 binding through altered conformational dynamics.

Burnap, Sean A; Struwe, Weston B

Burnap, Sean A; Struwe, Weston B.

Affiliation

Burnap SA; Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, OX1 3TA, UK. weston.struwe@chem.ox.ac.uk.
Struwe WB; The Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, South Parks Road, OX1 3QU, UK.

Chem Commun (Camb) ; 58(93): 12939-12942, 2022 Nov 22.

Article in En | MEDLINE | ID: mdl-36317551

Subject(s)

COVID-19; SARS-CoV-2; Humans; Angiotensin-Converting Enzyme 2; Spike Glycoprotein, Coronavirus/chemistry; Peptidyl-Dipeptidase A/metabolism; Receptors, Virus/chemistry; Receptors, Virus/metabolism; Protein Binding; Photometry; Molecular Dynamics Simulation; Binding Sites

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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