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Genome-wide association study for antibody response to Mycobacterium avium ssp. paratubeculosis in goats.
Minozzi, Giulietta; De Iorio, Maria Grazia; Palazzo, Fiorentina; Gandini, Gustavo; Biffani, Stefano; Paolillo, Gianluigi; Ciani, Elena; Di Marco Lo Presti, Vincenzo; Stella, Alessandra; Williams, John L.
Affiliation
  • Minozzi G; Department of Veterinary Medicine and Animal Sciences, Università degli Studi di Milano, Lodi, Italy.
  • De Iorio MG; Department of Veterinary Medicine and Animal Sciences, Università degli Studi di Milano, Lodi, Italy.
  • Palazzo F; Faculty of Bioscience and Technology for Food, Agriculture and Environment, Università degli Studi di Teramo, Teramo, Italy.
  • Gandini G; Department of Veterinary Medicine and Animal Sciences, Università degli Studi di Milano, Lodi, Italy.
  • Biffani S; Institute of Agricultural Biology and Biotechnology, National Research Council, Milano, Milano, Italia.
  • Paolillo G; Department of Veterinary Medicine and Animal Sciences, Università degli Studi di Milano, Lodi, Italy.
  • Ciani E; Department of Biosciences, Biotechnologies and Biopharmaceutics, Università degli Studi di Bari 'Aldo Moro', Bari, Italy.
  • Di Marco Lo Presti V; Istituto Zooprofilattico Sperimentale della Sicilia 'A. Mirri', Area Territoriale Barcellona Pozzo di Gotto, Messina, Italy.
  • Stella A; Institute of Agricultural Biology and Biotechnology, National Research Council, Milano, Milano, Italia.
  • Williams JL; School of Animal and Veterinary Sciences, Davies Research Centre, University of Adelaide, Adelaide, South Australia, Australia.
Anim Genet ; 54(1): 78-81, 2023 Feb.
Article in En | MEDLINE | ID: mdl-36321295
ABSTRACT
Mycobacterium avium ssp. paratuberculosis (MAP), causes Johne's disease (JD), or paratuberculosis, a chronic enteritis of ruminants, which in goats is characterized by ileal lesions. The work described here is a case-control association study using the Illumina Caprine SNP50 BeadChip to unravel the genes involved in susceptibility of goats to JD. Goats in herds with a high occurrence of Johne's disease were classified as healthy or infected based on the level of serum antibodies against MAP, and 331 animals were selected for the association study. Goats belonged to the Jonica (157) and Siriana breeds (174). Whole-genome association analysis identified one region suggestive of significance associated with an antibody response to MAP on chromosome 7 (p-value = 1.23 × 10-5 ). These results provide evidence for genetic loci involved in the antibody response to MAP in goats.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Paratuberculosis / Cattle Diseases / Goat Diseases / Mycobacterium avium subsp. paratuberculosis Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Anim Genet Journal subject: GENETICA / MEDICINA VETERINARIA Year: 2023 Document type: Article Affiliation country: Italy
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Paratuberculosis / Cattle Diseases / Goat Diseases / Mycobacterium avium subsp. paratuberculosis Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Anim Genet Journal subject: GENETICA / MEDICINA VETERINARIA Year: 2023 Document type: Article Affiliation country: Italy