Catalytic O2 activation toward oxidative N-S bond formation by a thiolato Fe(III) complex.
Chem Commun (Camb)
; 58(93): 12943-12946, 2022 Nov 22.
Article
in En
| MEDLINE
| ID: mdl-36321565
ABSTRACT
Compounds with the benzisothiazol-3-one (BIT) skeleton perform excellently in the pharmaceutical field, although current synthetic methods remain limited in terms of synthetic efficiency. Herein, we report the catalytic intramolecular N-S bond formation for BITs from easily prepared disulfide precursors by an Fe(III) dithiolate through O2 activation at 298 K. Interestingly, the catalytic performance is enhanced by substituting O2 with a milder O-donor oxidant, ONMe3. Catalytic oxygenation of PPh3 to OPPh3 can also proceed under similar conditions. In addition, the first anionic monosulfenato Fe(III) species, Fe(III)-S(îO)R, is isolated with structural characterization from the reaction of Fe(III) thiolate and ONMe3.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ferric Compounds
/
Oxidative Stress
Language:
En
Journal:
Chem Commun (Camb)
Journal subject:
QUIMICA
Year:
2022
Document type:
Article
Affiliation country:
Taiwan