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Electrochemically Mediated Carboxylative Cyclization of Allylic/Homoallylic Amines with CO2 at Ambient Pressure.
Pan, Yong-Zhou; Xia, Qiang; Zhu, Jin-Xiu; Wang, Ying-Chun; Liang, Ying; Wang, Hengshan; Tang, Hai-Tao; Pan, Ying-Ming.
Affiliation
  • Pan YZ; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, People's Republic of China.
  • Xia Q; School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin, Guangxi 541004, People's Republic of China.
  • Zhu JX; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, People's Republic of China.
  • Wang YC; College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, China.
  • Liang Y; School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin, Guangxi 541004, People's Republic of China.
  • Wang H; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, People's Republic of China.
  • Tang HT; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, People's Republic of China.
  • Pan YM; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, People's Republic of China.
Org Lett ; 24(44): 8239-8243, 2022 Nov 11.
Article in En | MEDLINE | ID: mdl-36322527
ABSTRACT
CO2 is an important C1 resource. We report a method for the synthesis of pharmacologically active 2-oxazolidinones by reacting CO2 with allylic amines. As opposed to previous addition reactions, the unsaturated double bonds are preserved. Thus, the product is more plastic and easier to use for subsequent structural modification. Furthermore, this method can also be applied to the synthesis of six-membered heterocycles (1,3-oxazinan-2-ones) and the participation of a low concentration of CO2, indicating it has certain practicability.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2022 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2022 Document type: Article