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Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants.
Desautels, Thomas A; Arrildt, Kathryn T; Zemla, Adam T; Lau, Edmond Y; Zhu, Fangqiang; Ricci, Dante; Cronin, Stephanie; Zost, Seth J; Binshtein, Elad; Scheaffer, Suzanne M; Dadonaite, Bernadeta; Petersen, Brenden K; Engdahl, Taylor B; Chen, Elaine; Handal, Laura S; Hall, Lynn; Goforth, John W; Vashchenko, Denis; Nguyen, Sam; Weilhammer, Dina R; Lo, Jacky Kai-Yin; Rubinfeld, Bonnee; Saada, Edwin A; Weisenberger, Tracy; Lee, Tek-Hyung; Whitener, Bradley; Case, James B; Ladd, Alexander; Silva, Mary S; Haluska, Rebecca M; Grzesiak, Emilia A; Earnhart, Christopher G; Hopkins, Svetlana; Bates, Thomas W; Thackray, Larissa B; Segelke, Brent W; Lillo, Antonietta Maria; Sundaram, Shivshankar; Bloom, Jesse; Diamond, Michael S; Crowe, James E; Carnahan, Robert H; Faissol, Daniel M.
Affiliation
  • Desautels TA; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Arrildt KT; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Zemla AT; Global Security Computing Applications Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Lau EY; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Zhu F; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Ricci D; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Cronin S; Vanderbilt Vaccine Center, Nashville, TN 37232, USA.
  • Zost SJ; Vanderbilt Vaccine Center, Nashville, TN 37232, USA.
  • Binshtein E; Vanderbilt Vaccine Center, Nashville, TN 37232, USA.
  • Scheaffer SM; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Dadonaite B; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Petersen BK; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Engdahl TB; Vanderbilt Vaccine Center, Nashville, TN 37232, USA.
  • Chen E; Vanderbilt Vaccine Center, Nashville, TN 37232, USA.
  • Handal LS; Vanderbilt Vaccine Center, Nashville, TN 37232, USA.
  • Hall L; Vanderbilt Vaccine Center, Nashville, TN 37232, USA.
  • Goforth JW; Global Security Computing Applications Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Vashchenko D; Applications Simulations and Quality Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Nguyen S; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Weilhammer DR; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Lo JK; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Rubinfeld B; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Saada EA; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Weisenberger T; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Lee TH; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Whitener B; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Case JB; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Ladd A; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Silva MS; Global Security Computing Applications Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Haluska RM; Applications Simulations and Quality Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Grzesiak EA; Global Security Computing Applications Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Earnhart CG; Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense, US, Department of Defense, Frederick, MD 21703, USA.
  • Hopkins S; Joint Research & Development, Inc., Stafford, VA 22556, USA.
  • Bates TW; Global Security Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Thackray LB; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Segelke BW; Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Lillo AM; Los Alamos National Laboratory, Bioscience Division, Los Alamos, NM 87545, USA.
  • Sundaram S; Center for Bioengineering, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  • Bloom J; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Diamond MS; Howard Hughes Medical Institute, Seattle, WA 98195, USA.
  • Crowe JE; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Carnahan RH; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Faissol DM; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
bioRxiv ; 2023 Apr 24.
Article in En | MEDLINE | ID: mdl-36324800
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: BioRxiv Year: 2023 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: BioRxiv Year: 2023 Document type: Article Affiliation country: United States Country of publication: United States