Exposure to levonorgestrel-based birth control pill in early life and its persistent effects in zebrafish.
Environ Toxicol Pharmacol
; 96: 104006, 2022 Nov.
Article
in En
| MEDLINE
| ID: mdl-36328330
ABSTRACT
The consumption of progestins has increased considerably in recent decades, as has their disposal into the environment. These substances can negatively affect the reproduction, physiology, and behavior of non-target organisms, such as fish. We aimed to evaluate the effects of exposure to environmentally relevant concentrations of levonorgestrel-control birth based (1.3, 13.3, 133, and 1330 ng/L) on the development and behavior of zebrafish (Danio rerio) in terms of mortality, hatching, spontaneous movement, and larval and adult behavioral tests. Exposure caused anxiogenic-like behavior in larvae, which persisted in adults, as demonstrated by the light-dark test. In contrast, it caused anxiolytic-like behavior in the novel tank test. There was a high mortality rate at all tested concentrations and increases in the hormone cortisol at 13.3 ng/L that affected the sex ratio. These changes may lead to an ecological imbalance, emphasizing the risk of early exposure to progestins in the environment.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Water Pollutants, Chemical
/
Zebrafish
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Environ Toxicol Pharmacol
Year:
2022
Document type:
Article
Affiliation country:
Brazil