A theoretical study on binding and stabilization of galactose and novel galactose analogues to the human &#945;-galactosidase A variant causing Fabry disease.

Klaewkla, Methus; Prousoontorn, Jittithorn; Charoenwongpaiboon, Thanapon

A theoretical study on binding and stabilization of galactose and novel galactose analogues to the human α-galactosidase A variant causing Fabry disease.

Klaewkla, Methus; Prousoontorn, Jittithorn; Charoenwongpaiboon, Thanapon.

Affiliation

Klaewkla M; Independent researcher, Bangkok 10800, Thailand.
Prousoontorn J; International School Bangkok, Nonthaburi 11120, Thailand.
Charoenwongpaiboon T; Department of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom 73000, Thailand. Electronic address: charoenwongpaib_t@su.ac.th.

Biophys Chem ; 292: 106915, 2023 01.

Article in En | MEDLINE | ID: mdl-36334502

Subject(s)

Fabry Disease; alpha-Galactosidase; Humans; alpha-Galactosidase/genetics; alpha-Galactosidase/chemistry; alpha-Galactosidase/metabolism; Fabry Disease/drug therapy; Fabry Disease/genetics; Galactose; Models, Theoretical; Mutation

Key words

Molecular dynamics; Pharmacological chaperone; Protein misfolding; α-galactosidase A

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fabry Disease / Alpha-Galactosidase Limits: Humans Language: En Journal: Biophys Chem Year: 2023 Document type: Article Affiliation country: Thailand

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