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Mapping prohormone processing by proteases in human enteroendocrine cells using genetically engineered organoid models.
Beumer, Joep; Bauzá-Martinez, Julia; Veth, Tim S; Geurts, Veerle; Boot, Charelle; Gilliam-Vigh, Hannah; Poulsen, Steen S; Knop, Filip K; Wu, Wei; Clevers, Hans.
Affiliation
  • Beumer J; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center (UMC) Utrecht, Oncode Institute, 3584 CT Utrecht, The Netherlands.
  • Bauzá-Martinez J; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CH Utrecht, The Netherlands.
  • Veth TS; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CH Utrecht, The Netherlands.
  • Geurts V; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center (UMC) Utrecht, Oncode Institute, 3584 CT Utrecht, The Netherlands.
  • Boot C; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center (UMC) Utrecht, Oncode Institute, 3584 CT Utrecht, The Netherlands.
  • Gilliam-Vigh H; Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.
  • Poulsen SS; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
  • Knop FK; Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.
  • Wu W; Steno Diabetes Center Copenhagen, 2730 Herlev, Denmark.
  • Clevers H; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Proc Natl Acad Sci U S A ; 119(46): e2212057119, 2022 11 16.
Article in En | MEDLINE | ID: mdl-36343264
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Hydrolases / Organoids Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Document type: Article Affiliation country: Netherlands
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Hydrolases / Organoids Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Document type: Article Affiliation country: Netherlands