A Rayleigh light scattering technique based on ß- cyclodextrin modified gold nanoparticles for phenytoin determination in exhaled breath condensate.
J Pharm Biomed Anal
; 223: 115141, 2023 Jan 20.
Article
in En
| MEDLINE
| ID: mdl-36356404
ABSTRACT
In the current work, a RLS technique based on ß-cyclodextrin modified gold nanoparticles was validated for phenytoin determination in the exhaled breath condensate. It relies on the complexation of ß-cyclodextrins using -OH groups with amine groups of phenytoin which results in an aggregation-induced Rayleigh light scattering intensity enhancement proportional to phenytoin addition. The method shows a linear relationship with phenytoin concentration in the range of 0.005-0.6 µg.mL-1 with a limit of detection of 0.003 µg.mL-1. The validated Rayleigh light scattering system is successfully used for phenytoin determination in the EBC of patients receiving phenytoin.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Beta-Cyclodextrins
/
Metal Nanoparticles
Limits:
Humans
Language:
En
Journal:
J Pharm Biomed Anal
Year:
2023
Document type:
Article
Affiliation country:
Iran