Development of a ternary cyclodextrin-arginine-ciprofloxacin antimicrobial complex with enhanced stability.
Commun Biol
; 5(1): 1234, 2022 11 12.
Article
in En
| MEDLINE
| ID: mdl-36371541
ABSTRACT
Designing useful functionalities in clinically validated, old antibiotics holds promise to provide the most economical solution for the global lack of effective antibiotics, as undoubtedly a serious health threat. Here we show that using the surface chemistry of the cyclodextrin (ßCD) cycle and arginine (arg) as a linker, provides more stable ternary antibiotic complex (ßCD-arg-cpx). In contrast to classical less stable inclusion complexes, which only modify antibiotic solubility, here-presented ternary complex is more stable and controls drug release. The components of the complex intensify interactions with bacterial membranes and increase the drug's availability inside bacterial cells, thereby improving its antimicrobial efficacy and safety profile. Multifunctional antibiotics, formulated as drug delivery systems per se, that take the drug to the site of action, maximize its efficacy, and provide optical detectability are envisaged as the future in fighting against infections. Their role as a tool against multiresistant strains remains as interesting challenge open for further research.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cyclodextrins
/
Beta-Cyclodextrins
Language:
En
Journal:
Commun Biol
Year:
2022
Document type:
Article
Affiliation country:
Slovenia