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Current State of 44Ti/44Sc Radionuclide Generator Systems and Separation Chemistry.
Schmidt, Christine E; Gajecki, Leah; Deri, Melissa A; Sanders, Vanessa A.
Affiliation
  • Schmidt CE; Department of Chemistry, Graduate Center of the City University of New York, New York, NY 10016, USA.
  • Gajecki L; Department of Chemistry, Lehman College of the City University of New York, New York 10468, USA.
  • Deri MA; Collider Accelerator Department, Brookhaven National Laboratory, Upton, NY 11973, USA.
  • Sanders VA; Department of Chemistry, Graduate Center of the City University of New York, New York, NY 10016, USA.
Curr Radiopharm ; 16(2): 95-106, 2023.
Article in En | MEDLINE | ID: mdl-36372922
ABSTRACT
In recent years, there has been an increased interest in 44Ti/44Sc generators as an onsite source of 44Sc for medical applications without needing a proximal cyclotron. The relatively short half-life (3.97 hours) and high positron branching ratio (94.3%) of 44Sc make it a viable candidate for positron emission tomography (PET) imaging. This review discusses current 44Ti/44Sc generator designs, focusing on their chemistry, drawbacks, post-elution processing, and relevant preclinical studies of the 44Sc for potential PET radiopharmaceuticals.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radioisotopes / Radiopharmaceuticals Language: En Journal: Curr Radiopharm Year: 2023 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radioisotopes / Radiopharmaceuticals Language: En Journal: Curr Radiopharm Year: 2023 Document type: Article Affiliation country: United States