Somatosensation a la mode: plasticity and polymodality in sensory neurons.
Curr Opin Physiol
; 11: 29-34, 2019 Jun 01.
Article
in En
| MEDLINE
| ID: mdl-36381588
ABSTRACT
Our understanding of how peripheral damage-sensing neurons (nociceptors) respond to noxious stimuli is fundamental to the development of effective analgesics. To date, numerous studies have presented diverging hypotheses on how nociceptors encode modality-specific stimuli, including labelled-line, intensity dependence or pattern theory. In this short review, we appraise data from electrophysiological, behavioural, imaging and molecular expression studies from the last 60 years, in order to obtain a coherent view of modality-specific sensing in peripheral sensory neurons. We propose a mechanistic explanation for the broad range of values obtained for the incidence of polymodal nociceptors that reconciles apparently contradictory data.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Curr Opin Physiol
Year:
2019
Document type:
Article
Affiliation country:
United kingdom