Clinical significance of the number of retrieved lymph nodes in early gastric cancer with submucosal invasion.
Medicine (Baltimore)
; 101(46): e31721, 2022 Nov 18.
Article
in En
| MEDLINE
| ID: mdl-36401371
ABSTRACT
The prognosis of early gastric cancer (EGC) with submucosal invasion is favorable; however, several cases of recurrence have been reported even after curative gastrectomy. This study aimed to investigate risk factors and evaluate the clinical significance of the number of retrieved lymph nodes (LNs) in EGC with submucosal invasion. We retrospectively analyzed the data of 443 patients with gastric cancer with submucosal invasion after curative gastrectomy for recurrent risk factors. Recurrence was observed in 22 of the 443 gastric cancer patients with submucosal invasion. In the univariate analysis, the risk factors for recurrence were the number of retrieved LNsâ
≤â
25 and node metastasis. In the multivariate analysis, retrieved LNsâ
≤â
25 (hazard ratio [HR]â
=â
5.754, P-valueâ
=â
.001) and node metastasis (HRâ
=â
3.031, P-valueâ
=â
.029) were independent risk factors for recurrence after curative gastrectomy. Body mass index was related to retrieved LNsâ
≤â
25 in univariate and multivariate analyses (HRâ
=â
.510, Pâ
=â
.002). The number of retrieved LNs and node metastases were independent risk factors for EGC with submucosal invasion. For EGC with submucosal invasion, retrieved LNsâ
>â
25 are necessary for appropriate diagnosis and treatment.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stomach Neoplasms
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Medicine (Baltimore)
Year:
2022
Document type:
Article