Cytomegalovirus reactivation in patients diagnosed with severe COVID-19: A point prevalence study in a general hospital.
Rev Esp Quimioter
; 36(1): 45-51, 2023 Feb.
Article
in En
| MEDLINE
| ID: mdl-36408974
ABSTRACT
OBJECTIVE:
To determine the prevalence of CMV reactivation in a population admitted for severe COVID-19 to a general hospital.METHODS:
Point prevalence study in all hospitalized patients with severe COVID-19 (admitted either to general wards or ICU). Determination of the presence of CMV DNA in circulating blood. COVID-19 was confirmed in patients with compatible clinical manifestations, usually with pneumonia and a positive nasopharyngeal PCR test.RESULTS:
We included 140 hospitalized patients with COVID-19 who consented to participate. A total of 16 patients (11.42%), had circulating CMV-DNA in peripheral blood at the time of the study. Patients with positive CMV viral load were mainly ICU patients (11/37 -29,7%) and only 5/103 cases (4,85%) were hospitalized into general wards. The accumulated doses of corticosteroids (prednisone equivalents) in the study day were (median and IQR) 987.50 mg (396.87-2,454.68) and 187.50 mg (75.00-818.12) respectively in CMV positive and negative patients (p < 0.001). A significant proportion of CMV positive patients were discovered because of the study and were clinically unsuspected by their physicians. The coinfected COVID-CMV positive population had a higher risk of accumulated secondary nosocomially-acquired infections and a worse prognosis.CONCLUSIONS:
CMV reactivation should be systematically searched in patients in COVID-19 cases admitted to the ICU.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cytomegalovirus Infections
/
COVID-19
Type of study:
Diagnostic_studies
/
Prevalence_studies
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Rev Esp Quimioter
Journal subject:
TERAPIA POR MEDICAMENTOS
Year:
2023
Document type:
Article
Affiliation country:
Spain