Cortical wiring by synapse type-specific control of local protein synthesis.
Science
; 378(6622): eabm7466, 2022 11 25.
Article
in En
| MEDLINE
| ID: mdl-36423280
ABSTRACT
Neurons use local protein synthesis to support their morphological complexity, which requires independent control across multiple subcellular compartments up to the level of individual synapses. We identify a signaling pathway that regulates the local synthesis of proteins required to form excitatory synapses on parvalbumin-expressing (PV+) interneurons in the mouse cerebral cortex. This process involves regulation of the TSC subunit 2 (Tsc2) by the Erb-B2 receptor tyrosine kinase 4 (ErbB4), which enables local control of messenger RNA {mRNA} translation in a cell type-specific and synapse type-specific manner. Ribosome-associated mRNA profiling reveals a molecular program of synaptic proteins downstream of ErbB4 signaling required to form excitatory inputs on PV+ interneurons. Thus, specific connections use local protein synthesis to control synapse formation in the nervous system.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Synapses
/
Protein Biosynthesis
/
Cerebral Cortex
/
Receptor, ErbB-4
/
Tuberous Sclerosis Complex 2 Protein
/
Interneurons
Limits:
Animals
Language:
En
Journal:
Science
Year:
2022
Document type:
Article
Affiliation country:
United kingdom