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Natural Reno-Protective Agents against Cyclosporine A-Induced Nephrotoxicity: An Overview.
Ibrahim, Sabrin R M; Abdallah, Hossam M; El-Halawany, Ali M; Mohamed, Gamal A; Alhaddad, Aisha A; Samman, Waad A; Alqarni, Ali A; Rizq, Akaber T; Ghazawi, Kholoud F; El-Dine, Riham Salah.
Affiliation
  • Ibrahim SRM; Preparatory Year Program, Department of Chemistry, Batterjee Medical College, Jeddah 21442, Saudi Arabia.
  • Abdallah HM; Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
  • El-Halawany AM; Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  • Mohamed GA; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
  • Alhaddad AA; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
  • Samman WA; Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  • Alqarni AA; Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah Al-Munawwarah 30078, Saudi Arabia.
  • Rizq AT; Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah Al-Munawwarah 30078, Saudi Arabia.
  • Ghazawi KF; Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  • El-Dine RS; Pharmaceutical Care Department, Ministry of National Guard-Health Affairs, Jeddah 22384, Saudi Arabia.
Molecules ; 27(22)2022 Nov 11.
Article in En | MEDLINE | ID: mdl-36431872
ABSTRACT
CA (cyclosporine A) is a powerful immunosuppressing agent that is commonly utilized for treating various autoimmune illnesses and in transplantation surgery. However, its usage has been significantly restricted because of its unwanted effects, including nephrotoxicity. The pathophysiology of CA-induced kidney injury involves inflammation, apoptosis, tubular injury, oxidative stress, and vascular injury. Despite the fact that exact mechanism accountable for CA's effects is inadequately understood, ROS (reactive oxygen species) involvement has been widely proposed. At present, there are no efficient methods or drugs for treating CA-caused kidney damage. It is noteworthy that diverse natural products have been investigated both in vivo and in-vitro for their possible preventive potential in CA-produced nephrotoxicity. Various extracts and natural metabolites have been found to possess a remarkable potential for restoring CA-produced renal damage and oxidative stress alterations via their anti-apoptosis, anti-inflammatory, and antioxidative potentials. The present article reviews the reported studies that assess the protective capacity of natural products, as well as dietary regimens, in relation to CA-induced nephrotoxicity. Thus, the present study presents novel ideas for designing and developing more efficient prophylactic or remedial strategies versus CA passive influences.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biological Products / Cyclosporine Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2022 Document type: Article Affiliation country: Saudi Arabia

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biological Products / Cyclosporine Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2022 Document type: Article Affiliation country: Saudi Arabia