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Response of Isolated Rat Heart to α2-Adrenergic Receptor Stimulation after If Current Blockade in the Late Postinfarction Period.
Bugrov, R K; Kuptsova, A M; Ziyatdinova, N I; Zefrov, T L.
Affiliation
  • Bugrov RK; Department of Human Health Protection, Kazan (Volga region) State University, Kazan, Republic of Tatarstan, Russia.
  • Kuptsova AM; Department of Human Health Protection, Kazan (Volga region) State University, Kazan, Republic of Tatarstan, Russia.
  • Ziyatdinova NI; Department of Human Health Protection, Kazan (Volga region) State University, Kazan, Republic of Tatarstan, Russia.
  • Zefrov TL; Department of Human Health Protection, Kazan (Volga region) State University, Kazan, Republic of Tatarstan, Russia. zefirovtl@mail.ru.
Bull Exp Biol Med ; 174(1): 22-25, 2022 Nov.
Article in En | MEDLINE | ID: mdl-36437345
ABSTRACT
We studied the effect of α2-adrenoreceptor activation after preliminary If-current blockade on the performance of the Langendorff-isolated rat heart 54 days after modeling myocardial infarction. Stimulation of α2-adrenoreceptors against the background of application of If blocker ZD7288 in concentrations of 10-9 and 10-5 M decreased myocardial inotropy in isolated rat hearts by 50 and 39% (p<0.05) and increased HR by 20 and 15% (p<0.05), respectively. Activation of α2-adrenoreceptors against the background of application of ZD7288 in a concentration of 10-9 and 10-5 M led to a decrease in the coronary flow in the isolated rat heart with the model of myocardial infarction by 21% (p<0.05) and 32% (p<0.05), respectively.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Adrenergic, alpha-2 / Myocardial Infarction Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2022 Document type: Article Affiliation country: RUSSIA
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Adrenergic, alpha-2 / Myocardial Infarction Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2022 Document type: Article Affiliation country: RUSSIA