A Systematic Review of COVID-19 Vaccine Antibody Responses in People With HIV.
Open Forum Infect Dis
; 9(11): ofac579, 2022 Nov.
Article
in En
| MEDLINE
| ID: mdl-36438620
ABSTRACT
HIV infection is a significant independent risk factor for severe coronavirus disease 2019 (COVID-19) disease and death. We summarize COVID-19 vaccine responses in people with HIV (PWH). A systematic literature review of studies from January 1, 2020, to March 31, 2022, of COVID-19 vaccine immunogenicity in PWH from multiple databases was performed. Twenty-eight studies from 12 countries were reviewed. While 22 (73%) studies reported high COVID-19 vaccine seroconversion rates in PWH, PWH with lower baseline CD4 counts, CD4/CD8 ratios, or higher baseline viral loads had lower seroconversion rates and immunologic titers. Data on vaccine-induced seroconversion in PWH are reassuring, but more research is needed to evaluate the durability of COVID-19 vaccine responses in PWH.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Risk_factors_studies
/
Systematic_reviews
Language:
En
Journal:
Open Forum Infect Dis
Year:
2022
Document type:
Article
Affiliation country:
United States