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Structure-guided design of novel HEPT analogs with enhanced potency and safety: From Isopropyl-HEPTs to Cyclopropyl-HEPTs.
Zhou, Ruo-Lan; Ju, Zhiran; Pannecouque, Christophe; Clercq, Erik De; Wang, Shuai; Chen, Fen-Er.
Affiliation
  • Zhou RL; Institute of Pharmaceutical Science and Technology, Zhejiang University of Technology, Hangzhou, 310014, China.
  • Ju Z; Institute of Pharmaceutical Science and Technology, Zhejiang University of Technology, Hangzhou, 310014, China.
  • Pannecouque C; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
  • Clercq E; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
  • Wang S; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai, 200433, China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai, 200433, China. Electronic address: shuaiwang@fudan.edu.cn.
  • Chen FE; Institute of Pharmaceutical Science and Technology, Zhejiang University of Technology, Hangzhou, 310014, China; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai, 200433, China; Shanghai Engineering Center of Industrial Asymmetric
Eur J Med Chem ; 246: 114939, 2023 Jan 15.
Article in En | MEDLINE | ID: mdl-36442370
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV-1 / Anti-HIV Agents Limits: Animals Language: En Journal: Eur J Med Chem Year: 2023 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV-1 / Anti-HIV Agents Limits: Animals Language: En Journal: Eur J Med Chem Year: 2023 Document type: Article Affiliation country: China