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Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties.
Sun, Ping; Wang, Jing; Khan, Khadija S; Yang, Weiqin; Ng, Billy Wai-Lung; Ilment, Nikita; Zessin, Matthes; Bülbül, Emre F; Robaa, Dina; Erdmann, Frank; Schmidt, Matthias; Romier, Christophe; Schutkowski, Mike; Cheng, Alfred Sze-Lok; Sippl, Wolfgang.
Affiliation
  • Sun P; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120 Halle/Saale, Germany.
  • Wang J; School of Biomedical Sciences, The Chinese University of Hong Kong, 999077 Hong Kong SAR, China.
  • Khan KS; School of Biomedical Sciences, The Chinese University of Hong Kong, 999077 Hong Kong SAR, China.
  • Yang W; School of Pharmacy, The Chinese University of Hong Kong, 999077 Hong Kong SAR, China.
  • Ng BW; School of Biomedical Sciences, The Chinese University of Hong Kong, 999077 Hong Kong SAR, China.
  • Ilment N; School of Pharmacy, The Chinese University of Hong Kong, 999077 Hong Kong SAR, China.
  • Zessin M; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120 Halle/Saale, Germany.
  • Bülbül EF; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120 Halle/Saale, Germany.
  • Robaa D; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120 Halle/Saale, Germany.
  • Erdmann F; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120 Halle/Saale, Germany.
  • Schmidt M; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120 Halle/Saale, Germany.
  • Romier C; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120 Halle/Saale, Germany.
  • Schutkowski M; Département de Biologie Structurale Intégrative, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, CNRS, INSERM, 67404 Illkirch Cedex, France.
  • Cheng AS; Department of Enzymology, Institute of Biotechnology, Martin-Luther University of Halle-Wittenberg, 06120 Halle/Saale, Germany.
  • Sippl W; School of Biomedical Sciences, The Chinese University of Hong Kong, 999077 Hong Kong SAR, China.
J Med Chem ; 65(24): 16313-16337, 2022 12 22.
Article in En | MEDLINE | ID: mdl-36449385
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Histone Deacetylase Inhibitors Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Germany Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Histone Deacetylase Inhibitors Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Germany Country of publication: United States