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Natural Compounds with BMI1 Promoter Inhibitory Activity from Mammea siamensis and Andrographis paniculata.
Fujii, Kazuki; Hara, Yasumasa; Arai, Midori A; Sadhu, Samir K; Ahmed, Firoj; Ishibashi, Masami.
Affiliation
  • Fujii K; Graduate School of Pharmaceutical Sciences, Chiba University.
  • Hara Y; Graduate School of Pharmaceutical Sciences, Chiba University.
  • Arai MA; Plant Molecular Science Center, Chiba University.
  • Sadhu SK; Faculty of Science and Technology, Keio University.
  • Ahmed F; Pharmacy Discipline, Khulna University.
  • Ishibashi M; Department of Pharmaceutical Chemistry, University of Dhaka.
Chem Pharm Bull (Tokyo) ; 70(12): 885-891, 2022.
Article in En | MEDLINE | ID: mdl-36450587
ABSTRACT
A new coumarin derivative (1) and 30 known compounds were isolated from Mammea siamensis and Andrographis paniculata, guided by B cell-specific Moloney murine leukemia virus insertion region 1 (BMI1) promoter inhibitory activity. Among the isolated compounds, 15 compounds showed BMI1 promoter inhibitory activity, and five compounds were found to be cytotoxic. 14-Deoxy-11,12-dehydroandrographolide (18) was highly cytotoxic to DU145 cells with an IC50 value of 25.4 µM. Western blotting analysis of compound 18 in DU145 cells suggested that compound 18 suppresses BMI1 expression.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mammea Limits: Animals Language: En Journal: Chem Pharm Bull (Tokyo) Year: 2022 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mammea Limits: Animals Language: En Journal: Chem Pharm Bull (Tokyo) Year: 2022 Document type: Article