Transfusion-Related Acute Lung Injury Caused by HLA-II Antibodies: A Case Report.

ABSTRACT

OBJECTIVE: The aim of this study was to retrospectively analyze the etiology of a case of suspected transfusion-related acute lung injury (TRALI) occurring after blood transfusion. METHODS: The clinical symptoms, signs, imaging examinations, and laboratory test results of a patient with suspected TRALI after blood transfusion were retrospectively analyzed, and human leukocyte antigen (HLA) genotyping of the patient and HLA antibodies of the plasma donors were performed. RESULTS: The clinical manifestations of the patient were consistent with those of TRALI after blood transfusion. This TRALI was treated by timely ventilator support. The patient results of high-resolution HLA genotyping were HLA-A* 0101, 1101; HLA-B* 1502, 3701; HLA-C* 0602, 0801; DRB1* 1001, 1202; DRB3* 0301, 0301; DQA1* 0105, 0601; DQB1* 0301, 0501; DPA1* 0103, 0201; and DPB1* 0201, 0901. Of the 6 plasma donors tested, 3 were found to have HLA-II antibodies, which were HLA-DPA1*0103, HLA-DQB1*0301, and HLA-DQB1*0301 antibodies. CONCLUSION: We described a case of TRALI caused by HLA-DQB1*0301 antibody and DPA1*0103 antibody.