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Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells.
Afzal, Junaid; Suhail, Yasir; Chang, Hao; Hubbi, Maimon E; Hamidzadeh, Archer; Goyal, Ruchi; Liu, Yamin; Sun, Peng; Nicoli, Stefania; Dang, Chi V; Levchenko, Andre.
Affiliation
  • Kshitiz; Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT 06032, USA; Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA. Electronic address: kshitiz@uchc.edu.
  • Afzal J; Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
  • Suhail Y; Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT 06032, USA; Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
  • Chang H; Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA; Yale Systems Biology Institute, Yale University, Orange, CT 06477, USA.
  • Hubbi ME; Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA; Department of Genetics, Yale University, New Haven, CT 06520, USA.
  • Hamidzadeh A; Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA; Yale Systems Biology Institute, Yale University, Orange, CT 06477, USA.
  • Goyal R; Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT 06032, USA; Yale Systems Biology Institute, Yale University, Orange, CT 06477, USA.
  • Liu Y; Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT 06032, USA.
  • Sun P; Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
  • Nicoli S; Department of Genetics, Yale University, New Haven, CT 06520, USA.
  • Dang CV; Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA; Ludwig Institute for Cancer Research, New York, NY 10016, USA; The Wistar Institute, Philadelphia, PA 19104, USA. Electronic address: cdang@lcr.org.
  • Levchenko A; Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA; Yale Systems Biology Institute, Yale University, Orange, CT 06477, USA. Electronic address: andre.levchenko@yale.edu.
Cell Syst ; 13(12): 1048-1064.e7, 2022 12 21.
Article in En | MEDLINE | ID: mdl-36462504
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lactic Acid / Chaperone-Mediated Autophagy Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cell Syst Year: 2022 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lactic Acid / Chaperone-Mediated Autophagy Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cell Syst Year: 2022 Document type: Article Country of publication: United States