FPT, a 2-Aminotetralin, Is a Potent Serotonin 5-HT1A, 5-HT1B, and 5-HT1D Receptor Agonist That Modulates Cortical Electroencephalogram Activity in Adult Fmr1 Knockout Mice.

Saraf, Tanishka S; McGlynn, Ryan P; Bhatavdekar, Omkar M; Booth, Raymond G; Canal, Clinton E

FPT, a 2-Aminotetralin, Is a Potent Serotonin 5-HT_1A, 5-HT_1B, and 5-HT_1D Receptor Agonist That Modulates Cortical Electroencephalogram Activity in Adult Fmr1 Knockout Mice.

Saraf, Tanishka S; McGlynn, Ryan P; Bhatavdekar, Omkar M; Booth, Raymond G; Canal, Clinton E.

Affiliation

Saraf TS; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, 3001 Mercer University Drive, Atlanta, Georgia 30341, United States.
McGlynn RP; Center for Drug Discovery, Department of Pharmaceutical Sciences, and Department of Chemistry and Chemical Biology, Northeastern University, 300 Huntington Street, Boston, Massachusetts 02115, United States.
Bhatavdekar OM; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 North Charles Street, Croft Hall B27, Baltimore, Maryland 21218, United States.
Booth RG; Center for Drug Discovery, Department of Pharmaceutical Sciences, and Department of Chemistry and Chemical Biology, Northeastern University, 300 Huntington Street, Boston, Massachusetts 02115, United States.
Canal CE; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, 3001 Mercer University Drive, Atlanta, Georgia 30341, United States.

ACS Chem Neurosci ; 13(24): 3629-3640, 2022 12 21.

Article in En | MEDLINE | ID: mdl-36473166

Subject(s)

Auditory Cortex; Fragile X Syndrome; Serotonin 5-HT1 Receptor Agonists; Adult; Animals; Female; Humans; Male; Mice; Auditory Cortex/metabolism; Disease Models, Animal; Electroencephalography; Fragile X Mental Retardation Protein/genetics; Fragile X Mental Retardation Protein/metabolism; Fragile X Syndrome/drug therapy; Mice, Knockout; Receptor, Serotonin, 5-HT1D; Serotonin; Serotonin 5-HT1 Receptor Agonists/pharmacology

Key words

5-HT1; EEG; Fmr1; alpha power; delta power; gamma power; serotonin

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Auditory Cortex / Serotonin 5-HT1 Receptor Agonists / Fragile X Syndrome Limits: Adult / Animals / Female / Humans / Male Language: En Journal: ACS Chem Neurosci Year: 2022 Document type: Article Affiliation country: United States Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google