Dehydroepiandrosterone Sulfate and Mortality in Middle-Aged and Older Men and Women-A J-shaped Relationship.
J Clin Endocrinol Metab
; 108(6): e313-e325, 2023 05 17.
Article
in En
| MEDLINE
| ID: mdl-36477484
ABSTRACT
CONTEXT The relationship between dehydroepiandrosterone sulfate (DHEAS) and mortality is of scientific and public health interest, yet it remains poorly understood. OBJECTIVE:
We examined the association between DHEAS and mortality from cancer, cardiovascular disease, and all causes in middle-aged and older men and women.METHODS:
DHEAS was measured in stored serum samples collected from 1994 to 1998 from a case-cohort nested within EPIC-Heidelberg, that included 7370 men (mean age = 55.0) and women (mean age = 52.4 years). Median follow-up for incident mortality events was 17.7 years. All deaths due to cancer (n = 1040), cardiovascular diseases (n = 598), and all causes (n = 2407) that occurred in EPIC-Heidelberg until end of 2014 were included.RESULTS:
The association between DHEAS and mortality was nonlinear such that both participants in the lowest (Q1) and highest (Q5) sex- and 5-year age-group specific quintiles of DHEAS were at increased hazard ratios (HR) of mortality from cardiovascular [Q1 HR = 1.83 (95% CI 1.33-2.51), Q5 1.39 (1.00-1.94)], cancer [Q1 1.27 (1.01-1.60), Q5 1.27 (1.02-1.60)] and all causes [Q1 1.51 (1.25-1.82), Q5 1.31 (1.08-1.58)], compared with participants in Q3. In men and women with below-median DHEAS levels, doubling of DHEAS was associated with lower hazards of cardiovascular [0.87, (0.78-0.96)], cancer [0.90, (0.83-0.97)], and total mortality [0.89, (0.83-0.95)]. In contrast, a doubling in DHEAS among participants with above-median levels was associated with 1.20, (1.01-1.42), 1.28, (1.01-1.62), and 1.19 (1.03-1.37) higher hazards of mortality from cancer, cardiovascular, and all causes, respectively.CONCLUSION:
In this large population-based study, DHEAS showed a J-shaped association with mortality. Both participants with lowest and highest levels experienced higher hazards of mortality from cancer, cardiovascular disease, and all causes.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cardiovascular Diseases
/
Neoplasms
Limits:
Aged
/
Female
/
Humans
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Male
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Middle aged
Language:
En
Journal:
J Clin Endocrinol Metab
Year:
2023
Document type:
Article
Affiliation country:
Germany