Impact of chemical structure on the in vitro hydrolysis of fatty esters of 2-ethylhexanoic acid or 2-ethylhexanol and extrapolation to the in vivo situation.

Obringer, Cindy; Lester, Cathy; Karb, Michael; Smith, Alex; Ellison, Corie A

Obringer, Cindy; Lester, Cathy; Karb, Michael; Smith, Alex; Ellison, Corie A.

Affiliation

Obringer C; The Procter & Gamble Company, Cincinnati, OH, 45040, USA.
Lester C; The Procter & Gamble Company, Cincinnati, OH, 45040, USA.
Karb M; The Procter & Gamble Company, Cincinnati, OH, 45040, USA.
Smith A; The Procter & Gamble Company, Cincinnati, OH, 45040, USA.
Ellison CA; The Procter & Gamble Company, Cincinnati, OH, 45040, USA. Electronic address: Ellison.ca@pg.com.

Regul Toxicol Pharmacol ; 137: 105315, 2023 Jan.

Article in En | MEDLINE | ID: mdl-36494001

Subject(s)

Esters; Liver; Humans; Hydrolysis; Metabolic Clearance Rate; Liver/metabolism

Key words

Alkyl fatty esters; Clearance; Ester metabolism; IVIVE; Liver; Plasma; Skin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Esters / Liver Limits: Humans Language: En Journal: Regul Toxicol Pharmacol Year: 2023 Document type: Article Affiliation country: United States Country of publication: Netherlands

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