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Mitochondrial Control in Inflammatory Gastrointestinal Diseases.
Sui, Guo-Yan; Wang, Feng; Lee, Jin; Roh, Yoon Seok.
Affiliation
  • Sui GY; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Republic of Korea.
  • Wang F; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Republic of Korea.
  • Lee J; Department of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Roh YS; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Republic of Korea.
Int J Mol Sci ; 23(23)2022 Nov 28.
Article in En | MEDLINE | ID: mdl-36499214
ABSTRACT
Mitochondria play a central role in the pathophysiology of inflammatory bowel disease (IBD) and colorectal cancer (CRC). The maintenance of mitochondrial function is necessary for a stable immune system. Mitochondrial dysfunction in the gastrointestinal system leads to the excessive activation of multiple inflammatory signaling pathways, leading to IBD and increased severity of CRC. In this review, we focus on the mitochondria and inflammatory signaling pathways and its related gastrointestinal diseases.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Inflammatory Bowel Diseases Limits: Humans Language: En Journal: Int J Mol Sci Year: 2022 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Inflammatory Bowel Diseases Limits: Humans Language: En Journal: Int J Mol Sci Year: 2022 Document type: Article