Your browser doesn't support javascript.
loading
Metabolic profiling and in vitro-in vivo extrapolation of furathiocarb in mammalian hepatic microsomes.
Abass, Khaled; Reponen, Petri; Alsanie, Walaa F; Rautio, Arja; Pelkonen, Olavi.
Affiliation
  • Abass K; Arctic Health, Faculty of Medicine, University of Oulu, P.O. Box 7300, FI-90014, Finland.
  • Reponen P; Pharmacology and Toxicology Unit, Research Unit of Biomedicine, University of Oulu, P.O. Box 5000, FI-90014 Oulu, Finland.
  • Alsanie WF; Department of Pesticides, Menoufia University, P.O. Box 32511, Egypt.
  • Rautio A; Pharmacology and Toxicology Unit, Research Unit of Biomedicine, University of Oulu, P.O. Box 5000, FI-90014 Oulu, Finland.
  • Pelkonen O; Department of Clinical Laboratory Sciences, The Faculty of Applied Medical Sciences & Centre of Biomedical Sciences Research (CBSR), Taif University, Saudi Arabia.
Toxicol Rep ; 9: 750-758, 2022.
Article in En | MEDLINE | ID: mdl-36518466
ABSTRACT
Furathiocarb is a carbamate insecticide found in marine ecosystems as well as river water and sediments. The aim of this study was to characterize species differences in the in vitro metabolism of furathiocarb in seven mammalian species (human, monkey, minipig, rat, mouse, dog, rabbit) analyzed by LC-TOF-MS/MS, in order to provide qualitative and quantitative chemical-specific data to enhance toxicological risk assessment. Furathiocarb was mainly biotransformed to carbofuran metabolic pathway via (N-S) bond-cleavage. Two hydroxylated and sulfoxidated metabolites of furathiocarb were also detected (oxidation pathway). No unique human metabolites were detected. The carbofuran metabolic pathway was more predominant than the furathiocarb oxidation pathway in all species studied; differences based on hepatic clearance rates (CL H ), were up to 9.4-fold in monkey and 7-fold in rats, while it was 4.3-fold in human. Animal to human differences in the carbofuran pathway are within the default toxicokinetic uncertainty factor, except for mouse (3.9-fold). Our findings on metabolic profiling and in vitro-in vivo extrapolations are helpful for the interpretation of toxicological findings and chemical risk assessment of furathiocarb.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Qualitative_research / Risk_factors_studies Language: En Journal: Toxicol Rep Year: 2022 Document type: Article Affiliation country: Finland

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Qualitative_research / Risk_factors_studies Language: En Journal: Toxicol Rep Year: 2022 Document type: Article Affiliation country: Finland