Haemorheologic Enhancement of Cerebral Perfusion Improves Oxygen Supply and Reduces Aß Plaques Deposition in a Mouse Model of Alzheimer's Disease.

Bragina, O A; Sillerud, L O; Kameneva, M V; Nemoto, E M; Bragin, D E

Bragina, O A; Sillerud, L O; Kameneva, M V; Nemoto, E M; Bragin, D E.

Affiliation

Bragina OA; Lovelace Biomedical Research Institute, Albuquerque, NM, USA. obragina@lrri.org.
Sillerud LO; Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Kameneva MV; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Nemoto EM; Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Bragin DE; Lovelace Biomedical Research Institute, Albuquerque, NM, USA.

Adv Exp Med Biol ; 1395: 335-340, 2022.

Article in En | MEDLINE | ID: mdl-36527658

Subject(s)

Alzheimer Disease; Plaque, Amyloid; Polymers; Animals; Mice; Alzheimer Disease/drug therapy; Alzheimer Disease/metabolism; Amyloid beta-Peptides/metabolism; Amyloid beta-Protein Precursor/metabolism; Brain/drug effects; Brain/metabolism; Cerebrovascular Circulation; Disease Models, Animal; Hypoxia/pathology; Mice, Transgenic; NAD/metabolism; Oxygen; Perfusion; Plaque, Amyloid/pathology; Polymers/metabolism; Polymers/pharmacology

Key words

2-photon laser scanning; Hypoperfusion; NADH autofluorescence; Neurodegeneration

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polymers / Plaque, Amyloid / Alzheimer Disease Limits: Animals Language: En Journal: Adv Exp Med Biol Year: 2022 Document type: Article Affiliation country: United States Country of publication: United States

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