Impact of middle cerebral artery pulsatility index on donor survival in twin-twin transfusion syndrome.
Prenat Diagn
; 43(1): 102-108, 2023 01.
Article
in En
| MEDLINE
| ID: mdl-36539914
ABSTRACT
OBJECTIVE:
To assess outcomes in twin-twin transfusion syndrome (TTTS) according to middle cerebral artery pulsatility index (MCA-PI) prior to fetoscopic laser photocoagulation (FLPC) surgery.METHODS:
A retrospective cohort analysis of monochorionic-twin pregnancies complicated by TTTS who underwent FLPC at two fetal centers (2012-2021). The cohort was stratified according to abnormal MCA-PI of the donor twin, defined as below fifth centile for gestational age.RESULTS:
Abnormal MCA-PI of the donor twin was detected in 46 (17.7%) cases compared to 213 (83.3%) controls with no such abnormality. The abnormal PI group presented with higher rates of sFGR (56.5% vs. 36.8% in controls, p = 0.014) and lower donor survival rates within 48 h after FLPC (73.9 vs. 86.8%, p = 0.029). Donor twin survival rates at the time of delivery and 30 days after birth were lower in the abnormal MCA-PI. Multivariate logistic regression analysis controlling for sFGR and MCA-PICONCLUSIONS:
Donor survival at the time of delivery and 30 days after birth was lower in TTTS cases with MCA-PI
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fetofetal Transfusion
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Prenat Diagn
Year:
2023
Document type:
Article
Affiliation country:
United States