Association of class II HLA alleles with susceptibility to develop immune-mediated diseases in Paraguayan patients.
Int J Immunogenet
; 50(1): 12-18, 2023 Feb.
Article
in En
| MEDLINE
| ID: mdl-36543746
ABSTRACT
Genetic and nongenetic factors are involved in the pathogenesis of immune-mediated inflammatory diseases (IMIDs). The best-known genetic factor for susceptibility to IMIDs is the human leukocyte antigen (HLA). The aim of the present study was to evaluate the association of HLA class II genes with the risk of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and systemic sclerosis (SSc) in the Paraguayan population. We included 254 patients with IMIDs (101 SLE, 103 RA, and 50 SSc) and 50 healthy controls. The haplotypes of five genes corresponding to HLA class II genes and their relationship to the IMIDs studied were determined. Note that 84.6% were women, with a mean age of 43.4 ± 14 years. Among the associated HLA alleles, we found the previously identified risk factors in other populations like HLA-DRB1*0301 and HLA-DRB1*1402 for RA, as well as new ones not previously identified, such as DPA1*0201 for SLE and, DB1*0201 for RA and SSc. In the genetic association analysis, already known associations have been replicated, and unpublished associations have been identified in Paraguayan patients with IMIDs. This is the first genetic association study in Paraguayan patients with IMIDs.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arthritis, Rheumatoid
/
Lupus Erythematosus, Systemic
Type of study:
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
America do sul
/
Paraguay
Language:
En
Journal:
Int J Immunogenet
Journal subject:
ALERGIA E IMUNOLOGIA
/
GENETICA
Year:
2023
Document type:
Article
Affiliation country:
Paraguay