Dysregulated Expression of Transposable Elements in TDP-43<sup>M337V</sup> Human Motor Neurons That Recapitulate Amyotrophic Lateral Sclerosis In Vitro.

Valdebenito-Maturana, Braulio; Rojas-Tapia, Matias Ignacio; Carrasco, Mónica; Tapia, Juan Carlos

Dysregulated Expression of Transposable Elements in TDP-43^M337V Human Motor Neurons That Recapitulate Amyotrophic Lateral Sclerosis In Vitro.

Valdebenito-Maturana, Braulio; Rojas-Tapia, Matias Ignacio; Carrasco, Mónica; Tapia, Juan Carlos.

Affiliation

Valdebenito-Maturana B; Instituto de Investigación Interdisciplinaria, Vicerrectoría Académica, Universidad de Talca, Campus Talca, Talca 3460000, Chile.
Rojas-Tapia MI; Escuela de Medicina, Universidad de Talca, Campus Talca, Talca 3460000, Chile.
Carrasco M; Escuela de Medicina, Universidad de Talca, Campus Talca, Talca 3460000, Chile.
Tapia JC; Escuela de Medicina, Universidad de Talca, Campus Talca, Talca 3460000, Chile.

Int J Mol Sci ; 23(24)2022 Dec 19.

Article in En | MEDLINE | ID: mdl-36555863

Subject(s)

Amyotrophic Lateral Sclerosis; Humans; Amyotrophic Lateral Sclerosis/metabolism; DNA Transposable Elements/genetics; Motor Neurons/metabolism; Mutation; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism

Key words

TAR DNA binding protein 43 (TDP-43); amyotrophic lateral sclerosis (ALS); transposable elements (TEs)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amyotrophic Lateral Sclerosis Limits: Humans Language: En Journal: Int J Mol Sci Year: 2022 Document type: Article Affiliation country: Chile Country of publication: Switzerland

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