Platelet-Rich Plasma in Chronic Wound Management: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
J Clin Med
; 11(24)2022 Dec 19.
Article
in En
| MEDLINE
| ID: mdl-36556151
ABSTRACT
BACKGROUND:
Chronic wounds place a heavy burden on the healthcare system due to the prolonged, continuous need for human resources for wound management. Our aim was to investigate the therapeutic effects of platelet-rich plasma on the treatment of chronic wounds.METHODS:
The systematic literature search was performed in four databases. Randomized clinical trials reporting on patients with chronic wounds treated with platelet-rich plasma (PRP) were included, comparing PRP with conventional ulcer therapy. We pooled the data using the random effects model. Our primary outcome was the change in wound size.RESULTS:
Our systematic search provided 2688 articles, and we identified 48 eligible studies after the selection and citation search. Thirty-three study groups of 29 RCTs with a total of 2198 wounds showed that the odds for complete closure were significantly higher in the PRP group than in the control group (OR = 5.32; CI 3.37; 8.40; I2 = 58%).CONCLUSIONS:
PRP is a safe and effective modality to enhance wound healing. By implementing it in clinical practice, platelet-rich plasma could become a widely used, valuable tool as it could not only improve patients' quality of life but also decrease the healthcare burden of wound management.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Clinical_trials
/
Systematic_reviews
Aspects:
Patient_preference
Language:
En
Journal:
J Clin Med
Year:
2022
Document type:
Article
Affiliation country:
Hungary
Publication country:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND