Human T-Cell Leukemia Virus Type 1-Related Diseases May Constitute a Threat to the Elimination of Human Immunodeficiency Virus, by 2030, in Gabon, Central Africa.
Viruses
; 14(12)2022 12 16.
Article
in En
| MEDLINE
| ID: mdl-36560812
ABSTRACT
The Joint United Nations Program on HIV/AIDS (UNAIDS) has adopted the Sustainable Development Goals (SDGs) to end the HIV/AIDS epidemic by 2030. Several factors related to the non-suppression of HIV, including interruptions of antiretroviral therapy (ART) and opportunistic infections could affect and delay this projected epidemic goal. Human T-Cell leukemia virus type 1 (HTLV-1) appears to be consistently associated with a high risk of opportunistic infections, an early onset of HTLV-1 and its associated pathologies, as well as a fast progression to the AIDS phase in co-infected individuals, when compared to HIV-1 or HTLV-1 mono-infected individuals. In Gabon, the prevalence of these two retroviruses is very high and little is known about HTLV-1 and the associated pathologies, leaving most of them underdiagnosed. Hence, HTLV-1/HIV-1 co-infections could simultaneously imply a non-diagnosis of HIV-1 positive individuals having developed pathologies associated with HTLV-1, but also a high mortality rate among the co-infected individuals. All of these constitute potential obstacles to pursue targeted objectives. A systematic review was conducted to assess the negative impacts of HTLV-1/HIV-1 co-infections and related factors on the elimination of HIV/AIDS by 2030 in Gabon.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Opportunistic Infections
/
Human T-lymphotropic virus 1
/
HTLV-I Infections
/
Leukemia, T-Cell
/
HIV Infections
/
Acquired Immunodeficiency Syndrome
/
HIV-1
/
HIV Seropositivity
/
Coinfection
Type of study:
Risk_factors_studies
/
Systematic_reviews
Limits:
Humans
Country/Region as subject:
Africa
Language:
En
Journal:
Viruses
Year:
2022
Document type:
Article
Affiliation country:
Gabon