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Pearls & Oy-sters: Salt and Pepper Sign, PLNTY for Drug-Resistant Epilepsy.
Paredes-Aragón, Elma M; AlKhaldi, Norah A; Burneo, Jorge G; Lee, Donald; Ang, Lee C; Steven, David; MacDonald, Maria; Herrera-Aramburú, Manuel; Mirsattari, Seyed M.
Affiliation
  • Paredes-Aragón EM; From the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophy
  • AlKhaldi NA; From the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophy
  • Burneo JG; From the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophy
  • Lee D; From the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophy
  • Ang LC; From the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophy
  • Steven D; From the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophy
  • MacDonald M; From the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophy
  • Herrera-Aramburú M; From the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophy
  • Mirsattari SM; From the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophy
Neurology ; 100(16): 791-795, 2023 04 18.
Article in En | MEDLINE | ID: mdl-36564206
ABSTRACT
Drug-resistant epilepsy, defined as the failure of 2 or more antiseizure medications to achieve seizure freedom, is responsible for 2/3 of epilepsy cases. Tumors are responsible for up to 15% of all adult onset and up to 6% of childhood onset epilepsies. Among these tumors, commonly known subtypes DNET, ganglioglioma, and low-grade astrocytoma are often suspected. New advances in tumor classification have been made, with genetics playing a key role in tumor classification. Polymorphic low-grade neuroepithelial tumor of the young (PLNTY) is a highly epileptogenic subtype of tumors that may mimic low-grade gliomas but offer pathologic and genetic clues oligodendroglioma-like cellular components and infiltration patterns and strong CD34-immunopositive stain. In addition, a key finding is radiologic a unifocal abnormality best seen on MRI brain in FLAIR sequence as the "salt and pepper sign" and calcifications appreciated on CT head.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligodendroglioma / Brain Neoplasms / Neoplasms, Neuroepithelial / Epilepsy / Drug Resistant Epilepsy / Glioma Limits: Humans Language: En Journal: Neurology Year: 2023 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligodendroglioma / Brain Neoplasms / Neoplasms, Neuroepithelial / Epilepsy / Drug Resistant Epilepsy / Glioma Limits: Humans Language: En Journal: Neurology Year: 2023 Document type: Article