Weight Loss and Alzheimer's Disease in Down Syndrome.
J Alzheimers Dis
; 91(3): 1215-1227, 2023.
Article
in En
| MEDLINE
| ID: mdl-36565120
ABSTRACT
BACKGROUND:
Virtually all adults with Down syndrome (DS) develop Alzheimer's disease (AD) pathology, but research gaps remain in understanding early signs of AD in DS.OBJECTIVE:
The goal of the present study was to determine if unintentional weight loss is part of AD in DS. The specific aims were to 1) examine relation between chronological age, weight, AD pathology, and AD-related cognitive decline were assessed in a large cohort of adults with DS, and 2) determine if baseline PET amyloid-ß (Aß) and tau PET status (-versus+) and/or decline in memory and mental status were associated with weight loss prior to AD progression.METHODS:
Analyses included 261 adults with DS. PET data were acquired using [11C] PiB for Aß and [18F] AV-1451 for tau. Body mass index (BMI) was calculated from weight and height. Direct measures assessed dementia and memory. Clinical AD status was determined using a case consensus process. Percent weight decline across 16-20 months was assessed in a subset of participants (nâ=â77).RESULTS:
Polynomial regressions indicated an 0.23âkg/m2 decrease in BMI per year beginning at age 36.5 years, which occurs alongside the period during which Aß and tau increase and memory and mental status decline. At a within-person level, elevated Aß, decline in memory and mental status were associated with higher percent weight loss across 16-20 months.CONCLUSION:
Unintentional weight loss occurs alongside Aß deposition and prior to onset of AD dementia, and thus may be a useful sign of AD in DS.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Down Syndrome
/
Alzheimer Disease
/
Cognitive Dysfunction
Aspects:
Patient_preference
Limits:
Humans
Language:
En
Journal:
J Alzheimers Dis
Journal subject:
GERIATRIA
/
NEUROLOGIA
Year:
2023
Document type:
Article
Affiliation country:
United States