Histopathological parameters reported in microinvasive oral squamous cell carcinoma: a systematic review.
Med Oral Patol Oral Cir Bucal
; 28(3): e255-e263, 2023 May 01.
Article
in En
| MEDLINE
| ID: mdl-36565223
ABSTRACT
BACKGROUND:
Microinvasive oral squamous cell carcinoma (OSCCmi) is an incipient stage of oral cancer. Through this systematic review, we aim to assess patterns of histopathological outcomes reported in OSCCmi cases. MATERIAL ANDMETHODS:
An online search in major databases was performed without period restriction, and 2,024 publications in English, Spanish and Portuguese were obtained. After screening and eligibility, 4 studies were selected. The risk of bias was assessed using Joanna Briggs Institute Critical Appraisal Checklist. A descriptive synthesis was conducted.RESULTS:
All 4 publications included were retrospective, reporting a total of 116 OSCCmi patients, with a male predominance (1.61) and a mean age of 55.9 years. The main parameters considered for microinvasion were tumor thickness (TT) (range 4-10mm) and depth of invasion (DOI) (range 0,02-5mm). Definition, cut-off values, and assessment of microscopic features were not standardized. Other relevant measures such as perineural or lymphovascular invasion and pattern of invasive front were barely described, and cytological/architectural characteristics were not discussed.CONCLUSIONS:
TT and DOI are currently the primary histopathological criteria used to define OSCCmi. Nonetheless, the outcomes of this systematic review showed the absence of standardized quantitative parameters to render the diagnosis of microinvasive OSCC. Therefore, additional studies aiming to standardize histopathological features to diagnose OSCCmi are paramount.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mouth Neoplasms
/
Carcinoma, Squamous Cell
/
Head and Neck Neoplasms
Type of study:
Systematic_reviews
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Med Oral Patol Oral Cir Bucal
Journal subject:
ODONTOLOGIA
Year:
2023
Document type:
Article
Affiliation country:
Brazil