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Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models.
Teuscher, Kevin B; Chowdhury, Somenath; Meyers, Kenneth M; Tian, Jianhua; Sai, Jiqing; Van Meveren, Mayme; South, Taylor M; Sensintaffar, John L; Rietz, Tyson A; Goswami, Soumita; Wang, Jing; Grieb, Brian C; Lorey, Shelly L; Howard, Gregory C; Liu, Qi; Moore, William J; Stott, Gordon M; Tansey, William P; Lee, Taekyu; Fesik, Stephen W.
Affiliation
  • Teuscher KB; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.
  • Chowdhury S; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.
  • Meyers KM; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.
  • Tian J; Molecular Design and Synthesis Center, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232-0142.
  • Sai J; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.
  • Van Meveren M; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.
  • South TM; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.
  • Sensintaffar JL; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.
  • Rietz TA; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.
  • Goswami S; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.
  • Wang J; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232-0004.
  • Grieb BC; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 37232-0004.
  • Lorey SL; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.
  • Howard GC; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-0011.
  • Liu Q; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.
  • Moore WJ; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.
  • Stott GM; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232-0004.
  • Tansey WP; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 37232-0004.
  • Lee T; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201.
  • Fesik SW; Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD 21701-4907.
Proc Natl Acad Sci U S A ; 120(1): e2211297120, 2023 01 03.
Article in En | MEDLINE | ID: mdl-36574664
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Intracellular Signaling Peptides and Proteins / WD40 Repeats / Neoplasms Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2023 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Intracellular Signaling Peptides and Proteins / WD40 Repeats / Neoplasms Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2023 Document type: Article