MGMT, a risk factor for both genetic and environmental forms of dementia.
Alzheimers Dement
; 19(5): 2208-2210, 2023 05.
Article
in En
| MEDLINE
| ID: mdl-36583449
ABSTRACT
MGMT, the gene coding for the DNA-repair protein O6 -methylguanine methyltransferase, which has been recently shown to be a risk factor for inherited forms of Alzheimer's disease (AD), notably among women, might also be linked to Western Pacific amyotrophic lateral sclerosis and Parkinsonism-dementia complex (ALS/PDC), one phenotype of which is an AD-like dementia. Guam ALS/PDC is strongly considered to be an environmental disorder caused by oral exposure to natural toxins (i.e., genotoxic/epigenotoxic chemicals), notably methylazoxymethanol (MAM) that alkylates guanine to form O6 -methylguanine, found in the seed of cycad plants traditionally used for food. Thus, the DNA-repair protein MGMT might participate in both AD and in the AD-related disorder ALS/PDC.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinsonian Disorders
/
Alzheimer Disease
/
Amyotrophic Lateral Sclerosis
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Alzheimers Dement
Year:
2023
Document type:
Article
Affiliation country:
United States