Knock down of TIMP-2 by siRNA and CRISPR/Cas9 mediates diverse cellular reprogramming of metastasis and chemosensitivity in ovarian cancer.

Escalona, Ruth M; Chu, Simon; Kadife, Elif; Kelly, Jason K; Kannourakis, George; Findlay, Jock K; Ahmed, Nuzhat

Escalona, Ruth M; Chu, Simon; Kadife, Elif; Kelly, Jason K; Kannourakis, George; Findlay, Jock K; Ahmed, Nuzhat.

Affiliation

Escalona RM; Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, 3052, Australia.
Chu S; Centre for Reproductive Health, Hudson Institute of Medical Research and Department of Translational Medicine, Monash University, Clayton, VIC, 3168, Australia.
Kadife E; Fiona Elsey Cancer Research Institute, Suites 23, 106-110 Lydiard Street South, Ballarat Technology Park Central, Ballarat, VIC, 3350, Australia.
Kelly JK; Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research and Department of Translational Medicine, Monash University, Clayton, VIC, 3168, Australia.
Kannourakis G; Fiona Elsey Cancer Research Institute, Suites 23, 106-110 Lydiard Street South, Ballarat Technology Park Central, Ballarat, VIC, 3350, Australia.
Findlay JK; Fiona Elsey Cancer Research Institute, Suites 23, 106-110 Lydiard Street South, Ballarat Technology Park Central, Ballarat, VIC, 3350, Australia.
Ahmed N; Fiona Elsey Cancer Research Institute, Suites 23, 106-110 Lydiard Street South, Ballarat Technology Park Central, Ballarat, VIC, 3350, Australia.

Cancer Cell Int ; 22(1): 422, 2022 Dec 30.

Article in En | MEDLINE | ID: mdl-36585738

Key words

CRISPR/Cas-9; Invasion; MMP14; MMP2; Migration; Ovarian cancer; Proliferation; TIMP-2; siRNA

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Cancer Cell Int Year: 2022 Document type: Article Affiliation country: Australia Country of publication: United kingdom

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