The evolution, characterization and phylogeography of avian influenza H9N2 viruses from India.
Virology
; 579: 9-28, 2023 02.
Article
in En
| MEDLINE
| ID: mdl-36587605
ABSTRACT
The low pathogenic avian influenza H9N2 virus is a significant zoonotic agent and contributes genes to highly pathogenic avian influenza (HPAI) viruses. H9N2 viruses are prevalent in India with a reported human case. We elucidate the spatio-temporal origins of the H9N2 viruses from India. A total of 30H9N2 viruses were isolated from poultry and environmental specimens (years 2015-2020). Genome sequences of H9N2 viruses (2003-2020) from India were analyzed, revealing several substitutions. We found five reassortant genotypes. The HA, NA and PB2 genes belonged to the Middle-Eastern B sublineage; NP and M to the classical G1 lineage; PB1, PA and NS showed resemblance to genes from either HPAI-H7N3/H5N1 viruses. Molecular clock and phylogeography revealed that the introduction of all the genes to India took place around the year 2000. This is the first report of the genesis and evolution of the H9N2 viruses from India, and highlights the need for surveillance.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Influenza A Virus, H5N1 Subtype
/
Influenza A Virus, H9N2 Subtype
/
Influenza in Birds
Limits:
Animals
/
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Virology
Year:
2023
Document type:
Article
Affiliation country:
India