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Pancancer analysis of SKA1 mutation and its association with the diagnosis and prognosis of human cancers.
Lan, Hua; Yuan, Jing; Zhang, Rui; Jiang, Biyao; Li, Qiaofen; Huang, Zongyan; Chen, Peiling; Xiang, Huimin; Zeng, Xiangyang; Xiao, Songshu.
Affiliation
  • Lan H; Department of Gynecology and Obstetrics, Third Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Gynecology and Obstetrics, Changsha Central Hospital of University of South China, Changsha, Hunan, China.
  • Yuan J; Department of Gynecology and Obstetrics, Third Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
  • Zhang R; Department of Gynecology and Obstetrics, Third Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Oncology, Huaihua Hospital of University of South China, Huaihua, Hunan, China.
  • Jiang B; Department of Gynecology and Obstetrics, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Li Q; Department of Gynecology and Obstetrics, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Huang Z; Department of Gynecology and Obstetrics, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Chen P; Department of Gynecology and Obstetrics, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Xiang H; Department of Gynecology and Obstetrics, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Zeng X; Department of Gynecology and Obstetrics, Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: zengxiangyang@csu.edu.cn.
  • Xiao S; Department of Gynecology and Obstetrics, Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: xiaosongshu@csu.edu.cn.
Genomics ; 115(2): 110554, 2023 03.
Article in En | MEDLINE | ID: mdl-36587749
ABSTRACT
This study aims to explore the role of SKA1 in cancer diagnosis and prognosis and to investigate the mechanism by which SKA1 affects the malignant behaviors of ovarian cancer. Herein, we analyzed the oncogenic role of SKA1 at pan-cancer level by multiple informatics databases and verified the analysis by in vitro experiments. As a result, SKA1 was upregulated across cancers and was related to poor clinical outcome and immune infiltration. Specifically, the constructed nomogram showed superior performance in predicting the prognosis of epithelial ovarian cancer patients. Furthermore, the in vitro experiments revealed that silencing SKA1 significantly inhibited the proliferation, migratory ability and enhanced the cisplatin sensitivity of ovarian cancer cells. Therefore, we explored the oncogenic and potential therapeutic role of SKA1 across cancers through multiple bioinformatic analysis and revealed that SKA1 may promote ovarian cancer progression and chemoresistance to cisplatin by activating the AKT-FOXO3a signaling pathway.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Cisplatin Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans Language: En Journal: Genomics Journal subject: GENETICA Year: 2023 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Cisplatin Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans Language: En Journal: Genomics Journal subject: GENETICA Year: 2023 Document type: Article Affiliation country: China