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The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition.
Koller, Timm O; Scheid, Ullrich; Kösel, Teresa; Herrmann, Jennifer; Krug, Daniel; Boshoff, Helena I M; Beckert, Bertrand; Evans, Joanna C; Schlemmer, Jan; Sloan, Becky; Weiner, Danielle M; Via, Laura E; Moosa, Atica; Ioerger, Thomas R; Graf, Michael; Zinshteyn, Boris; Abdelshahid, Maha; Nguyen, Fabian; Arenz, Stefan; Gille, Franziska; Siebke, Maik; Seedorf, Tim; Plettenburg, Oliver; Green, Rachel; Warnke, Anna-Luisa; Ullrich, Joachim; Warrass, Ralf; Barry, Clifton E; Warner, Digby F; Mizrahi, Valerie; Kirschning, Andreas; Wilson, Daniel N; Müller, Rolf.
Affiliation
  • Koller TO; Institute for Biochemistry and Molecular Biology, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany.
  • Scheid U; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarland University Campus, 66123 Saarbrücken, Germany.
  • Kösel T; Leibniz Universität Hannover, Institute of Organic Chemistry and Center for Biomolecular Drug Research (BMWZ), Schneiderberg 1B, 30167 Hannover, Germany.
  • Herrmann J; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarland University Campus, 66123 Saarbrücken, Germany.
  • Krug D; German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, 38124 Braunschweig, Germany.
  • Boshoff HIM; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarland University Campus, 66123 Saarbrücken, Germany.
  • Beckert B; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany.
  • Evans JC; German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, 38124 Braunschweig, Germany.
  • Schlemmer J; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, United States.
  • Sloan B; Institute for Biochemistry and Molecular Biology, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany.
  • Weiner DM; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, University of Cape Town, Rondebosch 7700, South Africa.
  • Via LE; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarland University Campus, 66123 Saarbrücken, Germany.
  • Moosa A; German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, 38124 Braunschweig, Germany.
  • Ioerger TR; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, United States.
  • Graf M; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, United States.
  • Zinshteyn B; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, United States.
  • Abdelshahid M; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, University of Cape Town, Rondebosch 7700, South Africa.
  • Nguyen F; Department of Computer Science and Engineering, Texas A&M University, College Station, Texas 77843, United States.
  • Arenz S; Institute for Biochemistry and Molecular Biology, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany.
  • Gille F; Department of Molecular Biology and Genetics, Johns Hopkins University, Baltimore, Maryland 21205, United States; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.
  • Siebke M; Institute for Biochemistry and Molecular Biology, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany.
  • Seedorf T; Institute for Biochemistry and Molecular Biology, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany.
  • Plettenburg O; Institute for Biochemistry and Molecular Biology, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany.
  • Green R; Leibniz Universität Hannover, Institute of Organic Chemistry and Center for Biomolecular Drug Research (BMWZ), Schneiderberg 1B, 30167 Hannover, Germany.
  • Warnke AL; Leibniz Universität Hannover, Institute of Organic Chemistry and Center for Biomolecular Drug Research (BMWZ), Schneiderberg 1B, 30167 Hannover, Germany.
  • Ullrich J; Institute of Medicinal Chemistry, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany.
  • Warrass R; Leibniz Universität Hannover, Institute of Organic Chemistry and Center for Biomolecular Drug Research (BMWZ), Schneiderberg 1B, 30167 Hannover, Germany.
  • Barry CE; Leibniz Universität Hannover, Institute of Organic Chemistry and Center for Biomolecular Drug Research (BMWZ), Schneiderberg 1B, 30167 Hannover, Germany.
  • Warner DF; Institute of Medicinal Chemistry, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany.
  • Mizrahi V; Department of Molecular Biology and Genetics, Johns Hopkins University, Baltimore, Maryland 21205, United States; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.
  • Kirschning A; Leibniz Universität Hannover, Institute of Organic Chemistry and Center for Biomolecular Drug Research (BMWZ), Schneiderberg 1B, 30167 Hannover, Germany.
  • Wilson DN; Institute of Medicinal Chemistry, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany.
  • Müller R; MSD Animal Health Innovation GmbH, Zur Propstei, 55270 Schwabenheim, Germany.
J Am Chem Soc ; 145(2): 851-863, 2023 01 18.
Article in En | MEDLINE | ID: mdl-36603206
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myxococcales / Mycobacterium tuberculosis Language: En Journal: J Am Chem Soc Year: 2023 Document type: Article Affiliation country: Germany Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myxococcales / Mycobacterium tuberculosis Language: En Journal: J Am Chem Soc Year: 2023 Document type: Article Affiliation country: Germany Country of publication: United States