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Safety Evaluation and Anti-Inflammatory Efficacy of Lacticaseibacillus paracasei PS23.
Li, Chin-Hao; Chen, Tai-Ying; Wu, Chien-Chen; Cheng, Shih-Hsuan; Chang, Min-Yu; Cheng, Wei-Hong; Chiu, Shih-Hau; Chen, Chien-Chi; Tsai, Ying-Chieh; Yang, Deng-Jye; Kang, Jaw-Jou; Liao, Po-Lin.
Affiliation
  • Li CH; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
  • Chen TY; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
  • Wu CC; Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.
  • Cheng SH; Bened Biomedical Co., Ltd., Taipei 104, Taiwan.
  • Chang MY; Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
  • Cheng WH; Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
  • Chiu SH; Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
  • Chen CC; Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu 300, Taiwan.
  • Tsai YC; Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu 300, Taiwan.
  • Yang DJ; Bened Biomedical Co., Ltd., Taipei 104, Taiwan.
  • Kang JJ; Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
  • Liao PL; Institute of Food Safety and Health Risk Assessment, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
Int J Mol Sci ; 24(1)2022 Dec 31.
Article in En | MEDLINE | ID: mdl-36614167
ABSTRACT
Lacticaseibacillus paracasei strain PS23 (PS23) exhibits some probiotic properties. In this study, a genomic analysis of PS23 revealed no genes related to virulence or antibiotic resistance. Moreover, ornithine decarboxylase activity was not detected in vitro. In addition, PS23 was sensitive to the tested antibiotics. Genotoxicity tests for PS23 including the Ames test and chromosomal aberrations in vitro using Chinese hamster ovary cells and micronuclei in immature erythrocytes of ICR mice were all negative. Moreover, following a 28-day study involving repeated oral dose toxicity tests (40, 400, and 4000 mg/kg equal 1.28 × 1010, 1.28 × 1011, and 1.28 × 1012 CFU/kg body weight, respectively) using an ICR mouse model, no adverse effects were observed from any doses. In addition, supplementation with live or heat-killed PS23 ameliorates DSS-induced colonic inflammation in mice. Our findings suggest that PS23 is safe and has anti-inflammatory effects and may therefore have therapeutic implications.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lacticaseibacillus paracasei Type of study: Prognostic_studies Limits: Animals Language: En Journal: Int J Mol Sci Year: 2022 Document type: Article Affiliation country: Taiwan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lacticaseibacillus paracasei Type of study: Prognostic_studies Limits: Animals Language: En Journal: Int J Mol Sci Year: 2022 Document type: Article Affiliation country: Taiwan